In a later study [168], we subjected APP/presenilin 1 transgenic (Tg) mice (APP/PS1 Tg), a transgenic mouse model of AD, to an extended sequence of repetitive low-level blast exposures (34.5 kPa, 5 psi) designed to mimic human subclinical blast exposures. This evidence concerns the gene PSEN1 and Alzheimer disease.