All of the genes constitutive of the SNARE complex (VAMP2-synaptobrevin; STX1A-synaptobrevin1; SPAP25 gene), except amysin, have already been described as being responsible for epilepsy, DEE, and/or neurodevelopmental disorders when mutated [31,32]. This evidence concerns the gene VAMP2 and developmental and epileptic encephalopathy.