This new function suggested for URG7 may explain observations previously reported in which overexpressed URG7 causes a reduction in unfolded proteins, an attenuation of ER stress induced by tunicamycin in HepG2 cells, and a change in the UPR with an increase in survival pathways compared to pro-apoptotic pathways as well as in neuroblastoma cell line SH-SY5Y [2,54]. The gene discussed is ABCC6; the disease is neuroblastoma.