ULK1 and Parkinson disease: In a cellular model of Lewy bodies disease, it was reported that upstream autophagy-related proteins, including ULK1, were localized in Lewy bodies, and their expression increased in parallel with the accumulation of inclusions; however, an analysis of total brain lysates in PD and DLB subjects did not show alterations in ULK1 levels, supporting the hypothesis that an impairment of upstream autophagy might occur in the pathogenesis of Lewy body disease with a resultingly altered autophagy process in an advanced stage of the disease [50].