After the role of TRPA1 on an acute model of glaucoma was shown, it was also demonstrated that TRPA1-/- knockout mice show a complete blockade of retinal damage (inhibiting the decrease in retinal thickness, increase in oxidative stress, and increase in the level of caspase activity) in a model of increased intraocular pressure and 2 or 7 days of reperfusion [172]. Here, TRPA1 is linked to glaucoma.