LRRK2 and major depressive disorder: By constructing the miRNAs–TFs-hub genes network, we found six miRNAs potentially interacting with at least two of the hub genes, of which two have been experimentally identified as downregulated in MDD and VDD: miR-146a-5p (targeting PTGS2) and miR-181c-5p (targeting both PTGS2 and LRRK2).