Furthermore, studies highlighting the mechanisms by which SREBP1c regulates hepatic stellate cells and liver fibrosis have revealed that the overexpression of SREBP1c inhibits liver fibrosis in mice by reducing TGF-β levels and signaling through SMAD3 and AKT1, AKT2, and AKT3 [65]. Here, AKT3 is linked to Hepatic fibrosis.