Ki et al. conducted a study that demonstrated that the mRNA and protein expression of GSH, the catalytic subunit of GCL (GCLC) and GSS were significantly increased in colon cancer cell lines including Caco 2, SNU 407, SNU 1033, HCT 116, and HT 29, compared to the normal colon cell line FHC. The gene discussed is GCLC; the disease is malignant colon neoplasm.