Ki et al. conducted a study that demonstrated that the mRNA and protein expression of GSH, the catalytic subunit of GCL (GCLC) and GSS were significantly increased in colon cancer cell lines including Caco 2, SNU 407, SNU 1033, HCT 116, and HT 29, compared to the normal colon cell line FHC. This evidence concerns the gene GCLC and colonic neoplasm.