SREBF1 and obesity due to melanocortin 4 receptor deficiency: In rodent models, dietary vitamin E intake protects against oxidative stress-related liver injury [17] and prevents sterol regulatory element-binding protein-1 (SREBP-1) maturation in HepG2 cells [16], whereas other antioxidants, such as resveratrol, curcumin, quercetin, and anthocyanin, have anti-inflammatory, anti-obesity, and anti-dyslipidemic functions [18].