This inhibits the immune-killing effects of NK cells and T cells, leading to a poor prognosis [47], while, the instability of defucosylation B7H3 after FUT8 silencing in CRC is due to the binding of HSC70 to B7H3 triggering its degradation through the chaperone-mediated autophagy pathway [82]. The gene discussed is FUT8; the disease is colorectal carcinoma.