We described that BMP7 promotes astrocytic differentiation of glioma-initiating cells by inducing the expression of the EMT transcription factor SNAIL in a SMAD1/5-dependent manner; the induction of Snail is required for BMP7 to be able to induce the expression of GFAP, an astrocytic marker [49]. The gene discussed is BMP7; the disease is central nervous system cancer.