Moreover, after the demonstration that TGF-β can control the exosome protein content in lung adenocarcinoma [44], it has been reported that the TGF-β-mediated exosomes have a high Lnc-MMP2-2 content, and that this noncoding RNA regulates lung cancer invasion and vascular permeability through the expression of MMP2 [45]; that, together with other matrix metalloproteinases, digests the extracellular matrix, facilitating the infiltration of malignant cells. This evidence concerns the gene MMP2 and lung adenocarcinoma.