A number of pathways, i.e., WP2118-arrhythmogenic right ventricular cardiomyopathy, WP2572-primary focal segmental glomerulosclerosis, WP2911-miRNA targets in ECM and membrane receptors, WP383-striated muscle contraction, WP4352-ciliary landscape, WP4754-IL-18 signaling pathway, were identified due to variants in structural protein-encoding genes. This evidence concerns the gene IL18 and Arrhythmogenic right ventricular dysplasia.