CYP3A4 and neoplasm: CYP-enzymes are diverse, and their activity is context-dependent: in vitro, CYP3A4 may accelerate tumor progression independently of oncogenes through arachidonic acid metabolism by activating the PI3K/AKT and STAT3 pathways [36] and stimulates angiogenesis through increased production of vascular endothelial growth factor (VEGF) [37].