Lastly, miR-125a-5p is also downregulated in psoriasis lesions; the methyltransferase EZH2 catalyzes the methylation of histone H3 at lysine 27, repressing transcription of miR-125a-5pn [231] and eventually leading to increased expression of IL-17A-induced cytokines and cell proliferation [213]. The gene discussed is IL17A; the disease is psoriasis.