An analysis of DNA methylation profiles identified hypomethylated genes, such as IFI44, IFITM1, Y-box binding protein 1 (YBX1), and TATA-box binding protein associated factor 8 (TAF8), and hypermethylated genes, including SRY-box transcription factor 12 (SOX12), ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3), coiled-coil domain containing 81 (CCDC81), and maternally expressed 3 (MEG3), in SLE B cells [96]. Here, SOX12 is linked to systemic lupus erythematosus.