In PBMCs from SLE patients, the levels of H3K4me3 are increased in WD repeat-containing protein 5 (WDR5) and solute carrier family 24 member 3 (SLC24A3) genes, and decreased in protein tyrosine phosphatase non-receptor type 22 (PTPN22), methyltransferase 16 (METTL16), LDL receptor-related protein 1B (LRP1B), and cadherin 13 (CDH13) genes [98]. The gene discussed is PTPN22; the disease is systemic lupus erythematosus.