MAPT and frontotemporal dementia: The impact of different mutations in the MAPT gene encoding for the Tau protein was studied in cerebral organoids derived from patients with FTD, demonstrating significant differences in the expression of several genes, including the ceramide synthetase genes CERS4, CERS5 and CERS6, and PINI, TBK1, FUS and ELAV4 [78,121].