Consequently, CXCRs have been implicated in various diseases; for example, the CXCR3 and CXCR5 receptors have been implicated in autoimmune conditions, such as multiple sclerosis (MS) [24], rheumatoid arthritis (RA) [29,30], and cutaneous lupus erythematosus (CLE) [31,32]. The gene discussed is CXCR3; the disease is rheumatoid arthritis.