SPP1 and systemic lupus erythematosus: The frequencies of the haplotype rs1126616 and rs9138 variants of the SPP1 gene in patients stratified by SLE with LN and SLE without LN are depicted in Table 4, where statistically significant differences are observed in the TA haplotype in patients with LN (21%; 25/120) as a risk factor (OR 2.8, 95% CI 1.4–5.3, p = 0.002).