For instance, m6A methyltransferase METTL3 promotes NAFLD-HCC [36], while METTL14 curbs the metastasis of HCC by regulating the EGFR/PI3K/AKT signaling pathway in a manner that depends on m6A methylation [37]. This evidence concerns the gene METTL3 and metabolic dysfunction-associated steatotic liver disease.