PTK2B and oculodentodigital dysplasia: Significantly, a recent interesting study has demonstrated that mutations at Cx43′s CaM-binding site at CT, but not at CL2, in the autosomal-dominant pleiotropic disorder called oculodentodigital dysplasia (ODDD) inhibit gap junction formation by limiting phosphorylation by Pyk2 and Src [120].” This study further confirms evidence for both a role of CaM in gap junction assembly [119] and evidence for CaM binding to CL2 and CT [42,43,44].