CAV3 is also expressed in the cardiac muscle and, even if rare, cases of associations between mutations in its sequence with cardiac diseases have been reported, including long QT syndrome (LQTS), atrial fibrillation (AF), sudden infant death syndrome (SIDS) and hypertrophic cardiomyopathy (HCM) [4,13,14,15,16]. Here, CAV3 is linked to hypertrophic cardiomyopathy.