Cognitive decline (↑); Synapsin I level (+);IL-4 expression (+);M2-like microglial activation and neuroprotection;Proinflammatory cytokines expression (such as TNF-α and IL-1β, TNF-α, IL-6, and IL-1β) (−);Aβ clearance by invoking Aβ degrading factors (+). This evidence concerns the gene SYN1 and Mental deterioration.