Two of these miRNAs in previous HCC studies demonstrated mIR-373-3p targeting TFAP4/CDH1/CSDC2 and PPP6C [72,73,74,75], and miR-1290 targeting SMEK1/FOXC1/SLU7/GLIPR1. This evidence concerns the gene PPP4R3A and hepatocellular carcinoma.