IGF1R and hepatocellular carcinoma: The miR-122 family modulates proliferation, invasion and apoptosis in HCC pathogenesis by targeting PBF, ADAM10/Cyclin G1 and Igf1R/ADAM 17/BCL-W/NDRG3 [39,40,97,132,133], as well by influencing EMT, cell migration, invasion and metastasis [97,134].