In the HBx dysregulated HBV-HCC pathways, this panel of MIRNAs can influence a number of genes in the TGF-B/SMAD pathway by targeting validated gene targets like TGFBR1/SMAD3/, CDKN1A and MYC to influence both oncogenesis and the loss of tumor suppression. The gene discussed is SMAD3; the disease is neoplasm.