Let-7 family members can also modulate angiogenesis/growth/migration and inflammation, as well as modulate TP53 tumor suppressor function by targeting STAT3/RAS/HMGA2/MYC/IL-6/IL-10/TLR-4/COL1A2 and NGF /BCL-XL [64,92,136,137]. This evidence concerns the gene COL1A2 and neoplasm.