Similarly, miR-142-3p, which has been reported as upregulated in fibrogenesis in the PME [113], is one of our top 10 downregulated miRNAs targeting LDHA/HMGB1/ RAC1, ZEB1/CD133 and SLC3A2 in HBV-HCC [122,123,124,125,126,127]. This evidence concerns the gene HMGB1 and hepatocellular carcinoma.