Additionally, they used rimonabant, a selective CB1 antagonist, and SR144528, a CB2 antagonist, to block cannabinoid receptors in HPV-positive HNSCC and found that these receptor antagonists not only inhibited cell proliferation but also triggered apoptosis in HPV-positive HNSCC cells [99]. The gene discussed is CNR2; the disease is head and neck squamous cell carcinoma.