Thus, the current study aims to evaluate the microbial profiles in samples obtained from peri-implantitis lesions and correlate the findings with the characterization of the inflammatory process, particularly with respect to the expression of the inflammasomes AIM2 and NLRP3 as well as caspase-1 and interleukin-1β. This evidence concerns the gene NLRP3 and Peri-Implantitis.