Lin and colleagues sought to improve PDT effects by modulating tumor hypoxia and used in vitro and in vivo mice models of orthotopic BC to investigate the effect of Chlore6-based PS enhanced with oxygen-producing nanoparticles (HSA-MnO2-Ce6 NPs: HSA—human serum albumin, Ce6—Chlore6, NPs—nanoparticles). This evidence concerns the gene ALB and breast cancer.