In 2016, Pradhan et al. evaluated the CRP value of 64 patients fulfilling the criteria for SIRS (systemic inflammatory response syndrome) admitted to ICU (with 51 of them further diagnosed with sepsis), and reported, for this marker, a sensitivity of 84.3%, a specificity of 46.15%, positive predictive value (PPV) of 84%, and negative predictive value (NPV) of 42.8%, with the best diagnostic accuracy at 61 mg/L [111]. This evidence concerns the gene CRP and systemic inflammatory response syndrome.