Given the importance of the enzyme peptidyl arginine deaminase 4 (PAD4) in NETs formation, and the evidence that PAD4-deficient mice exhibit less organ damage and higher survival rate in a model of sepsis, it has been reported that the treatment of mice with CI-Amidine, a pharmacologic inhibitor of PAD4, decreases NETs formation and improves survival rates in sepsis [189,190]. This evidence concerns the gene PADI4 and Sepsis.