Recent evidence from a Schizophrenia Exome Meta-Analysis (SCHEMA) consortium study also implicates protein-damaging mutations affecting synaptic genes, including the NMDA receptor subunit GRIN2A, the AMPA receptor subunit GRIA3 and a synaptic voltage-gated calcium channel (CACNA1G) [10]. The gene discussed is GRIN2A; the disease is schizophrenia.