NSD3 and acute myeloid leukemia: The first NSD3 fusion protein was found in a patient with AML, where the t(8;11) (p11.2;p15) translocation fuses the NUP98 gene to the 3′ end of NSD3 containing both of the PWWP, the SET, PHD and CH5CH rich domains (Figure 3A) [40].