The degree of lamina propria remodeling, demonstrated with Mason trichrome staining in esophageal biopsies obtained from children with EoE, before and after at least 3 months of therapy with budesonide, reduced fibrosis among responders, where TGF-β1- and pSmad2/3-positive cells were diminished [113]. This evidence concerns the gene TGFB1 and eosinophilic esophagitis.