Kawasaki, T. et al. [57] applied MIR with a power density of 35–45 mJ/cm2 and wavelengths of 5.00 μm, 6.17 μm and 7.19 μm to irradiate PS, APP and tau AD transgenic mouse brain slices, and the results showed that 5.0 μm MIR could dissociate Aβ in brain slices of AD model mice. Here, MAPT is linked to Alzheimer disease.