Notably, Silvani et al. observed an inactivation of the yes-associated protein 1 (YAP1) in glioblastoma cells, suggesting that this protein represents a molecular entry point and that mechanical unloading inhibited proliferation of the glioblastoma cells due to the inactivation of YAP1 convoyed by the absence of anchoring points to the actin cytoskeleton resulting in reduced cellular structural stability [86]. The gene discussed is YAP1; the disease is glioblastoma.