The other important findings from this study were dysregulation of EIF2C1 and EIF2C3 (components of RNA-induced silencing complex), TLE3 (WD40 repeat domain protein), RPS27A (ribosomal protein), APH1B, PSEN2, and PSENEN (involved in γ-secretase complex and Alzheimer’s disease), TLE1, TLE2, and FBXW7 (WD40 repeat domain proteins), SMAD1, SMAD2, and SMAD3 (involved in microRNA maturation) DROSHA and DICER (core components of miRNA processing). The gene discussed is PSEN2; the disease is early-onset autosomal dominant Alzheimer disease.