PSENEN and early-onset autosomal dominant Alzheimer disease: The other important findings from this study were dysregulation of EIF2C1 and EIF2C3 (components of RNA-induced silencing complex), TLE3 (WD40 repeat domain protein), RPS27A (ribosomal protein), APH1B, PSEN2, and PSENEN (involved in γ-secretase complex and Alzheimer’s disease), TLE1, TLE2, and FBXW7 (WD40 repeat domain proteins), SMAD1, SMAD2, and SMAD3 (involved in microRNA maturation) DROSHA and DICER (core components of miRNA processing).