In particular, (auto)antigenic stimulation and signaling through the B-cell receptor (BCR) play a critical role in the pathogenesis and progression of CLL, which is evidenced by the strong prognostic and predictive relevance of the BCR composition (i.e., somatic hypermutational status of immunoglobulin heavy-variable (IGHV) genes and BCR stereotypy) [31,32]. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.