However, multivariate Cox analysis controlling for Binet stage (A + B vs. C) and cytogenetic risk (favorable + intermediate vs. unfavorable) showed that MALAT1 expression was not an independent predictor of OS in U-CLL (HR = 0.625, 95% CI = 0.337−1.161, p = 0.137). This evidence concerns the gene MALAT1 and B-cell chronic lymphocytic leukemia.