However, the authors observed that MALAT1 expression was positively correlated to the expression of genes involved in pathways related to activation, proliferation, and survival of CLL cells in the lymph nodes (PI3K/AKT, MAPK, IL4, IL10), suggesting that microenvironmental stimuli may trigger MALAT1 upregulation [39]. This evidence concerns the gene MALAT1 and B-cell chronic lymphocytic leukemia.