Besides recurrent chromosomal aberrations (del13q14, trisomy 12, del11q22-23, del17p13) and mutations of protein-coding genes (NOTCH1, SF3B1, ATM, TP53, BIRC3, etc.), alterations of non-coding RNAs have also been detected in CLL. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.