Multivariate Cox regression analysis controlling for Binet stage (A + B vs. C) and cytogenetic risk (favorable + intermediate vs. unfavorable) showed a trend toward the independent association of MALAT1 expression with TTFT in U-CLL (hazard ratio (HR) = 0.581, 95% CI = 0.337−1.002, p = 0.051). Here, MALAT1 is linked to B-cell chronic lymphocytic leukemia.