TGFB1 and aneurysm: Indeed, Cook et al. reported that treating Fbn1mgR/mgR mice with TGFβ neutralizing antibodies before aneurysm formation (starting from 16 days after birth) exacerbated TAA formation; however, when the treatment was initiated after aneurysm formation (starting from 45 days after birth), the intervention mitigated TAA development and improved survival [148].