AKT1 and polycystic ovary syndrome: In the study, the upregulation of miRNA-339-5p was found to inhibit the migration, proliferation, and tubular formation of EPCs by inhibiting silent information regulator 1/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (SIRT1/PGC-1α) and PI3K/AKT signaling pathways, making PCOS women more prone to developing CVD [61].