More notably, ischemic preconditioning with the BBB permeable Nrf2 activator 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-trifluoethyl amide was shown to reduce sensorimotor deficits, post-stroke cognitive impairments, and brain tissue loss in mice [136]. Here, NFE2L2 is linked to stroke disorder.