MAPT and tauopathy: Under pathological conditions, specifically during the development of tauopathies, genetic mutations or persistent environmental stimuli activate metabolic cascades that lead to changes in the cellular environment, which inhibit the activity of phosphatases and promote the overexpression of kinases, disrupting the balance between the two forms of tau by causing the hyperphosphorylation of tau and inducing a conformational change in tau that prevents its binding to microtubules [5,24,55,56,57].