GDF-15 blood levels were proposed to be a clinically relevant biomarker within the context of MetS, as they have been associated with several MetS components, such as hyperglycemia, hypertension, and hyperlipidemia [67,68,69,70,71], high waist circumference, WHR and CRP, and low HDL-C [18,72]. This evidence concerns the gene CRP and Hyperglycemia.