GDF15 and obesity due to melanocortin 4 receptor deficiency: This result agrees with a series of regression analyses (Table 2 and Table 3) that show that MetS is significantly and independently correlated with body composition parameters, particularly the markers of obesity (FM/WT and ECW/ICW ratio), the adipose tissue-related adipokine L/A ratio, the inflammation-related factors as assessed by using MHR, and the multifunctional aging biomarker GDF-15 [53].