Evidently, various HMTs, including the Suppressor of Variegation 3–9 Homolog 2 (SUV39H2) [79] and SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) [80] were associated with CRC liver metastasis. Here, SETDB1 is linked to colorectal carcinoma.