Among the dysregulated LSDs, Lysine Demethylase 3A (KDM3A) and LSD1 showed elevated expression levels in metastatic lesion tissue compared to paired CRC primary tissue (p-value < 0.001) and distant metastasis in primary tissue (p-value < 0.05), respectively [81,82,83]. This evidence concerns the gene KDM3A and colorectal carcinoma.