Thus, while in group A, Tnf was positively correlated with the asthma degree, in the AO group, it positively correlated with the HOMA (Homeostasis model assessment) index and resistin, indicating that, in the case of AO, changes in feces induced by obesity are more important than those promoted by allergies (Figure 3A). Here, RETN is linked to obesity due to melanocortin 4 receptor deficiency.