P2RX7 and mood disorder: The above process has been suggested to play a significant role in the impact of chronic stress, leading to impaired neuroplasticity and the emergence of depressive-like behaviour, while pharmacological or genetic blockade of the P2RX7-NLRP3-IL1β pathway might foster resilience against stress via the involvement of microglia and monocytes, suggesting the potential role of P2X7R signalling as a connecting point between chronic stress and mood disorder [91,92].