P2RX7 and mood disorder: Although several studies, including GWAS-s [38], suggest a relationship between chromosome 12q2431, where P2RX7 gene is located, and the development of mood disorders [39,40], whose association with suicide is evident, and despite the increasing attention focusing on the role of neuroinflammation and suicide, there have been no studies investigating the involvement of the P2X7 receptor and the P2RX7 gene in suicidal behaviour.