The evolution of non-liver fluke-associated CCA is suggested to be associated more with FGFR2 fusions than in liver fluke-associated CCA as FGFR fusions in fluke-associated and non-fluke-associated CCA were 0.8% and 11.6%, respectively (p = 0.0006) [22]. Here, FGFR2 is linked to cholangiocarcinoma.