Additionally, 10-acetylirciformonin B has been shown to exhibit antitumor properties in leukemia HL60 cells via promoting DNA destruction and apoptosis through several signaling pathways; notably, 10-acetylirciformonin B induced caspase-3 and caspase-9 activity and decreased topoisomerase II protein production [96]. This evidence concerns the gene CASP9 and leukemia.