The molecular mechanism by which Lamellarin D induces apoptosis has been described in p388 leukemia cells, where it increased the rate of Bax, stimulated the activity of caspase-3 and caspase-9 and decreased that of Bcl-2, and finally promoted the depolarization of mitochondria, as well as nuclear apoptosis [66,67]. This evidence concerns the gene CASP3 and leukemia.