Similarly, by increasing the level of PP2A, the supplementation of rutin, an antioxidant with neuroprotective activities found widely in fruits, such as apricots, cherries, grapefruit and oranges [126,127,128], significantly reduced tau hyperphosphorylation in the brains of Tau-P301S mice overexpressing the P301S mutant form of human tau while rescuing synapse loss and preventing cognitive decline [129]. The gene discussed is MAPT; the disease is Mental deterioration.