The abnormal aggregation of tau protein has been found in a group of neurodegenerative diseases known as tauopathies, including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) [6,7,8]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.