MAPT and Alzheimer disease: In addition to enhancing the acetylation of HSP90 and expression of HSC70, protopine derivative bromo-protopine, a better HDAC6 inhibitor in comparison with the parent compound, has been shown to increase the expression of lysosomal-associated membrane protein type 2A, a receptor of chaperone-mediated autophagy, thus promoting tau degradation via chaperone-mediated autophagy in AD models [165].