NPM1 and acute myeloid leukemia: In general, the cytoplasmic mislocation of AML-NPM1 dysregulates several cellular processes, leading to uncontrolled centrosome duplication, the inhibition of tumor suppressor genes, the activation of caspase 6 and 8 proteolytic activities, impairment of the DNA repair pathways and the activation of the Myc oncogene [57].