As shown in a recent paper, neutralization of VEGF in the CM of hypoxic A549 and H358 lung cancer cells resulted in significant inhibition of the otherwise stimulatory effect of the CM on VEGFR2 phosphorylation of HUVECs, confirming the critical role of VEGF in mediating the angiogenic capacities of these cells [20]. Here, VEGFA is linked to lung carcinoma.