Cells in NSCLC employ a combination of antioxidant defenses and survival signaling, including the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, metabolic adaptations, DNA repair mechanisms, and adaptation to hypoxic conditions, to manage and sustain proliferation in the presence of oxidative stress during glycolysis [84,85,86,87]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.