Circulating and tissue proinflammatory cytokines such as tumor TNF-α, interferon-γ, interleukin (IL)-6, and IL-12, vascular cell adhesion molecular 1, and monocyte chemoattractant protein-1 can impair insulin metabolic signaling and decrease insulin-mediated NO production, leading to arterial stiffening, hypertension, and other diabetic vasculopathy [1]. The gene discussed is INS; the disease is hypertensive disorder.