Comparing the two types of HF (HFpEF and HFrEF), there are notable differences in plasma concentrations of both BNP and NT-proBNP, which is understandable considering that natriuretic peptides reflect increased tensional stress in the LV wall rather than pressures of LV filling, with this tensional stress being lower in HFpEF compared to HFrEF. This evidence concerns the gene NPPB and hydrops fetalis.