In a rat model of CKD, capsaicin could inhibit the osteogenic trans-differentiation of vessels by acting either on TRPV1 activation and HIF-1α degradation through the upregulation of Sirtuin 6 [77]; such a double, synergic mechanism to prevent vascular calcification by capsaicin would absolutely deserve additional target investigations to ascertain whether this natural compound could indeed represent a valid therapeutic option for ameliorating this serious and still irreversible complication of CKD. This evidence concerns the gene TRPV1 and chronic kidney disease.